Search results for "Modified folfirinox"

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Modified FOLFIRINOX versus CisGem first-line chemotherapy for locally advanced non resectable or metastatic biliary tract cancer (AMEBICA)-PRODIGE 38…

2019

IF 3.287 (2017); International audience; IntroductionCombination of cisplatine and Gemcitabine (CisGem) is the reference 1st line Chemotherapy in patients with advanced biliary cancer. FOLFIRINOX demonstrated an overall survival superiority when compared to gemcitabine in 1st line for patients with metastatic pancreatic adenocarcinoma. Because of similarities between pancreatic and biliary cancers, we proposed a randomized trial comparing mFOLFIRINOX and CisGEm.AimPRODIGE38-AMEBICA is a phase II/III trial evaluating efficacy of modifed FOLFIRINOX (D1 bolus removed) or CisGEm on patients with locally advanced non resectable or metastatic biliary tract cancer.Patients and methodsMain inclusio…

Malemedicine.medical_specialtyFOLFIRINOXmedicine.medical_treatmentModified folfirinoxLeucovorinAntineoplastic Agents[SDV.CAN]Life Sciences [q-bio]/CancerAdvanced biliary cancerIrinotecanDeoxycytidineGastroenterology03 medical and health sciences0302 clinical medicineInternal medicineAntineoplastic Combined Chemotherapy ProtocolsCarcinomaHumansMedicineNeoplasm InvasivenessNeoplasm StagingChemotherapyHepatologybusiness.industryGallbladderCarcinomaGastroenterologyMetastatic Pancreatic Adenocarcinomamedicine.diseaseGemcitabinePrimary tumorGemcitabine3. Good healthOxaliplatinmedicine.anatomical_structureBile Duct NeoplasmsBiliary tract030220 oncology & carcinogenesisFemale030211 gastroenterology & hepatologyFluorouracilFranceCisplatinDrug Monitoringbusinessmedicine.drug

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PEPhysical Sciences and Engineering
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